The endogenous mouse Ifngr1 gene was replaced by human IFNGR1 gene.

Validation Data

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Figure 1. Detection of IFNGR1 expression by RT-PCR. Wild type: only one band at 271 bp with primers F2/R2 (mIfngr1); Homozygous: only one band at 296 bp with primers F1/R1 (hIFNGR1); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Figure 2. Validation of hCD119 (IFNGR1) expression in blood by FACS. 

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Figure 3. Validation of hCD119 (IFNGR1) expression in spleen by FACS.

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Figure 4. Validation of hCD119 (IFNGR1) expression in bone marrow by FACS. 

Size

Mouse

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