The endogenous mice H2-Ab1 gene was replaced by human HLA-DPB1*04:01 gene.
Figure 1. Detection of HLA-DPB1*04:01 expression in spleen by RT-PCR. Wild type: only one band at 372 bp with primers F1/R1 (mH2-Ab1); Heterozygous: one band at 372 bp with primers F1/R1 (mH2-Ab1) and one band at 362 bp with primers F2/R2 (hHLA-DPB1*04:01); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
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