The endogenous mouse Il12a gene was replaced by human IL12A gene.
Figure 1. Detection of IL12A expression in spleen by RT-PCR. Wild type: only one band at 198 bp with primers F1/R1 (mIl12a); Homozygous: only one band at 488 bp with primers F2/R2 (hIL12A); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
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