R26-(CAG-LSL-dCas9-VPR-IRES-EGFP-WPRE-pA)

These mice harbor a CAG-LSL-dCas9-VPR(VP64-p65-Rta)-eGFP-pA conditional expression cassette in mouse Rosa26 loci by CRISPR/Cas mediated homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).