Col1a1-(TRE3G-dCas9-VPR-eGFP-pA)

SKU ASKI-00123 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-00123
Model Name	Col1a1-(TRE3G-dCas9-VPR-eGFP-pA)
Strain Name	C57BL/6J-Col1a1^{em1(TRE3G-dCas9-VPR-eGFP-pA)Asc}
Background	C57BL/6J
Coat Color	Black
Model Type	Knock-in
Research Application	Immunotherapy

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci by CRISPR/Cas mediated homologous recombination. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

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