| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-215004 |
|
Model Name |
GCGR |
|
Strain Name |
C57BL/6JSmoc-Gcgrem(hGCGR)Smoc |
|
GENE Synonyms |
GR |
|
Human Orthologs |
GCGR |
|
Ensembl ID |
ENSMUSG00000025127 |
|
MGI ID |
99572 |
|
NCBI ID |
14527 |
|
Background |
C57BL/6J |
|
Coat Color |
Black |
|
Model Type |
Humanized |
|
Model Color |
Black |
The endogenous mice Gcgr gene was replaced by human GCGR gene.
Figure 1. Detection of GCGR expression in liver by RT-PCR.
Wild type: only one band at 261 bp with primers F1/R1 (mGcgr); Heterozygous: one band at 261 bp with primers F1/R1 (mGcgr) and one band at 223 bp with primers F2/R2 (hGCGR); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Figure 2. Detection of human GCGR expression in liver in hGCGR knockin mice by IHC.
Liver were collected from wild-type mice (+/+) and homozygous hGCGR mice (HO/HO), and analyzed by IHC with anti-human GCGR antibody.
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