Leverage the power of iPSCs in a smaller, less immunogenic package
Building on the powerful hiEX™ Research iPSC Exosome platform, Applied StemCell provides you with a range of iPSC exosome services to align exosome design and formulation with your specific research goals.
Whether you require engineered exosomes for therapeutic payload delivery, enrichment with specific miRNAs or proteins, or lineage-specific differentiation prior to harvest, we can tailor your hiEX™ iPSC Exosomes to meet your project needs.
We also offer custom formulation options and the ability to scale into GMP manufacturing for clinical applications.
From basic research to early-stage discovery to preclinical development, custom hiEX™ iPSC Exosomes give you a flexible, future-ready solution for advancing your scientific programs.
Our expertise in iPSCs, cell line engineering, and cell product GMP manufacturing provides unique capabilities for customizing your isolated exosomes.
Developed by the innovators at Applied StemCell, TARGATT™ large knock-in technology is used in many of our cell line engineering projects to overexpress one or more genes in mammalian cells.
With the ability to efficiently and site-specifically knock-in up to 20 kb of DNA in a single reaction—more in nested reactions—TARGATT™ technology is a highly effective way for us to engineer iPSCs so that your exosomes are enriched for a specific protein or miRNA.
The power of iPSCs lies in their ability to provide a consistent and scalable source of human cells that are morphologically and functionally similar to the equivalent primary cell.
Before isolating exosomes, we can differentiate the parent iPSC line into the cell type of your choice. The exosomes we isolate will have the batch-to-batch consistency you can’t get if you isolate exosomes from tissue originating from different donors.
We routinely build cell-based models of disease by editing iPSCs and then differentiating into the desired cell type.
By combining our gene editing and iPSC expertise, we can efficiently create custom cell-based disease models and then isolate exosomes, to achieve your research goals.
Explore the therapeutic and immunogenic potential of exosomes isolated from our knock-in ready hypoimmunogenic iPSC line, ActiCells™ RUO TARGATT™ Hypo hiPSCs.
We can isolate exosomes directly from this line or engineer the line to your specifications, including using our powerful TARGATT™ large knock-in technology for efficient site-specific integration and expression of your gene(s) of interest.
Because our hiEX™ Research iPSC Exosomes are isolated from our ActiCells™ GMP TARGATT™ iPSCs (Cat.# AST-9480), we can efficiently adjust hiEX™ iPSC Exosome manufacturing to be GMP-compliant.
While off-the-shelf hiEX™ Research iPSC Exosomes are available in vials of 10 x 109 particles in 1 mL of PBS, we can customize the concentration and formulation of your order, including through lyophilization or the addition of specific ingredients such as hyaluronic acid.
Don’t see what you need? Reach out to our team and we’ll provide solutions to help you achieve your project goals.
With over 1,800 unique cell line models engineered by the scientists and technology developers at Applied StemCell, you can be confident in the quality and reliability of our service.
We pride ourselves on clear and frequent communication, including letting you know ahead of time of any challenges we foresee with your project.
With over 15 years in business delivering and innovating in the iPSC and genome editing space, we have the experience and optimized processes to deliver success.
Our cell line engineering projects deliver over 98% projects completed to our customers' specifications
All projects completed at our facilities in California (cell-based projects) and Oklahoma (animal projects)
Start a customized hiEX™ Exosome service or learn more about our capabilities by submitting the form below. We will get back to you within one business day.
