CCR8 (2)

SKU ASHU-2000054 Categories Immune Checkpoint Mouse Models, Mouse Models, Products

Strain Information

Table Header	Table Header
Catalog Number	ASHU-2000054
Model Name	CCR8 (2)
Strain Name	C57BL/6-Ccr8^{em3(hCCR8)/Asc}
GENE Synonyms	C-C, CCR-8, CKR-8, mCCR8, Cmkbr8, CC-CKR-8, C-C CKR-8
Human Orthologs	CCR8
Ensembl ID	ENSMUSG00000042262
MGI ID	1201402
NCBI ID	12776
Background	C57BL/6
Coat Color	Black
Mutation Type	Humanized
Model Type	Humanized
Research Application	Immunotherapy, drug screening
Model Color	Black

Humanized Strategy

Humanized CCR8 Protein Sequence

Alignment of Human and Humanized CCR8 Protein

Overall Proportions of Immune Cells in the Blood of Humanized CCR8 Mouse

hCCR8 Expression Validation in Humanized CCR8

Binding of Anti-hCCR8 to Spleen-derived T cells in Humanized CCR8 Mouse

In vivo Validation of Humanized CCR8 Mice

Figure 1. In vivo validation of humanized CCR8 mice. Humanized CCR8 mice were inoculated with MC38 colon cancer cells, and were randomly assigned into different groups when the tumors grew to a volume of 100 mm3. Human-specific, CCR8 antibody was given in divided doses every 2 to 3 days for three weeks (Data in partnership with collaborators).

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