| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-200114 |
|
Model Name |
CD20 (2) |
|
Strain Name |
C57BL/6-Ms4a1tm2 (hCD20)/Asc |
|
GENE Synonyms |
cd20, Ly-44, Ms4a1, AA960661 |
|
Human Orthologs |
CD20 |
|
Ensembl ID |
ENSMUSG00000024673 |
|
MGI ID |
88321 |
|
NCBI ID |
12482 |
|
Background |
C57BL/6 |
|
Coat Color |
Black |
|
Mutation Type |
Humanized |
|
Model Type |
Humanized |
|
Research Application |
Immune-related, drug screening |
|
Model Color |
Black |
Figure1. Human CD20 expression on B cells is confirmed by FACS analysis in the heterozygous humanized CD20 mice. The heterozygous KI animal expresses both human and murine CD20 on CD19+ B cells.
Figure 2. Human CD20 expression on CD45+ cells is confirmed by FACS analysis in WT, heterozygous, and homozygous humanized CD20 mice. The WT animal expresses mouse CD20 on CD45+ cells, and the homozygous KI expresses human CD20, while the heterozygous KI expresses both human and murine CD20.
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