Description

Humanized Strategy

landingpage-ashu-190011-cd28-hu-icpmouse-1

Validation Data

landingpage-ashu-190011-cd28-hu-icpmouse-4

Figure 1. Expression characterization of hCD28 on T cells in blood in hCD28 KI mice

landingpage-ashu-190011-cd28-hu-icpmouse-5

Figure 2. Expression characterization of hCD28 on T cells in spleen in hCD28 KI mice

landingpage-ashu-190011-cd28-hu-icpmouse-6

Figure 3. Expression characterization of hCD28 on T cells in thymus in hCD28 KI mice

landingpage-ashu-190011-cd28-hu-icpmouse-7

Figure 4. In vivo efficacy study in CD28 humanized mice grafted with MC38-hPDL1 tumor model