CD38 (2)

Strain Information

Table Header Table Header
Catalog Number
ASHU-190059
Model Name
CD38
Strain Name
C57BL/6-Cd38em2(CD38)/Asc
GENE Synonyms
I-19, ADPRC 1, Cd38-rs1
Human Orthologs
CD38
Ensembl ID
ENSMUSG00000029084
MGI ID
107474
NCBI ID
12494
Background
C57BL/6
Coat Color
Black
Mutation Type
Humanized
Model Type
Humanized
Research Application
Immunotherapy, cancer research, drug screening
Model Color
Black

Humanized Strategy

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Validation Data

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Figure 1. Detection of CD38 expression in live cells from PBMC of humanized CD38 mice.

The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from PBMC of Homozygous humanized CD38 mice.

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Figure 2. Detection of CD38 expression in live cells from the spleen of humanized CD38 mice.

The FACS results showed that the high expression of humanized CD38 was detected in B, T, NK cells from the spleen of Homozygous humanized CD38 mice.

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Figure 3. In vivo anti-tumor effect of Daratumumab, a humanized anti-CD38 antibody, in a humanized mouse model of CD38

Homozygous humanized CD38 mice were inoculated with E.G7-­OVA T lymphoma cells. The results showed: Daratumumab, a drug targeting human CD38, showed a very significant anti-tumor effect, demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.( Data in partnership with collaborators )

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