| Table Header | Table Header |
|---|---|
Catalog Number | ASHU-220120 |
Model Name | CD3EDG |
Strain Name | C57BL/6-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/Asc |
GENE Synonyms | CD3, T3e, AI504783, CD3epsilon; T3d; T3g, Ctg3, Ctg-3 |
Human Orthologs | CD3E; CD3D; CD3G |
Ensembl ID | ENSMUSG00000032093; ENSMUSG00000032094; ENSMUSG00000002033 |
MGI ID | 88332; 88331; 88333 |
NCBI ID | 12501; 12500; 12502 |
Background | C57BL/6 |
Coat Color | Black |
Model Type | Humanized |
Model Color | Black |
The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.
Figure 1. Expression detection of human CD3E/CD3D/CD3G by FACS in homozygous hCD3EDG mice.
Figure 2. Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to evaluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody in parallel with homozygous hCD3EDG mice.
Figure 3. Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to evaluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.
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