| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-190074 |
|
Model Name |
CSF1R(2) |
|
Strain Name |
C57BL/6-Csf1rem2(hCSF1R)/Asc |
|
GENE Synonyms |
Fms, Fim2, CD115, Csfmr, Fim-2, CSF-1R, M-CSFR, M-CSF-R, AI323359 |
|
Human Orthologs |
CSF1R |
|
Ensembl ID |
ENSMUSG00000024621 |
|
MGI ID |
1339758 |
|
NCBI ID |
12978 |
|
Background |
C57BL/6 |
|
Coat Color |
Black |
|
Mutation Type |
Humanized |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy, cancer research, drug screening |
|
Model Color |
Black |
Figure 1. Detection of CSF1R(2) expression in spleen by RT-PCR.
Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2)); Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Figure 2. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in huCSF-1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008, BMS, phase II）
Figure 3. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in huCSF-1R mice.
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