H11-pThy1-hPSEN1-IRES-tdTomato

SKU ASKI-18049 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-18049
Model Name	H11-pThy1-hPSEN1-IRES-tdTomato
Strain Name	C57BL/6-Igs2^{em1(pThy1-PSEN1-IRES-tdTomato-WPRE-pA)/Asc}
Background	C57BL/6
Coat Color	Black
Model Type	Knock-in
Research Application	Alzheimer research
Model Color	Black

A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) by CRISPR/Cas9 gene editing technology.

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