| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-2000068 |
|
Model Name |
ICOSL (2) |
|
Strain Name |
C57BL/6J-Icosltm3(hICOSLG)/Asc |
|
GENE Synonyms |
B7h, GI50, GL50, B7-H2, LICOS, B7RP-1, GL50-B, ICOS-L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653 |
|
Human Orthologs |
ICOSLG |
|
Ensembl ID |
ENSMUSG00000000732 |
|
MGI ID |
1354701 |
|
NCBI ID |
50723 |
|
Background |
C57BL/6J |
|
Coat Color |
Black |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy, drug screening |
|
Model Color |
Black |
The endogenous mouse Icosl gene was replaced by human ICOSLG gene.
Figure 1. Analysis of ICOSLG gene expression in the spleen by RT-PCR. Mouse Icoslg mRNA was detectable by P1/2 (276bp), human ICOSLG mRNA was detectable by P1/3 (406bp), M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human ICOSLG and mouse Icoslg in the spleen.
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