| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-210372 |
|
Model Name |
IL11 & IL11RA |
|
Strain Name |
C57BL/6J-Il11em1(hIL11)Il11ra1tm1(hIL11RA)/Asc |
|
GENE Synonyms |
IL-11; NR1, GP130, Il11ra, Il-11ra, Il11ra2, AI314697 |
|
Human Orthologs |
IL11; IL11RA1 |
|
Ensembl ID |
ENSMUSG00000004371; ENSMUSG00000073889 |
|
MGI ID |
107613; 107426 |
|
NCBI ID |
16156; 16157 |
|
Background |
C57BL/6J |
|
Coat Color |
Black |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy, drug screening |
|
Model Color |
Black |
hIL11(ASHU-204981) was crossed with hIL11RA (ASHU-204982) to generate hIL11/hIL11RA mice.
Figure 1. Detection of IL11 and IL11RA expression in testis, stomach and lung by RT-PCR. Wild type: only one band at 171 bp with primers F1/R1 (mIl11); Homozygous: only one band at 162 bp with primers F2/R2 (hIL11). Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Figure 2. Detection of hIL11 expression in lung homogenate by ELISA. Abbr. HO, homozygous; WT, wild type. Note. hIL11/hIL11RA and C57BL/6 mice were injected with LPS.
Figure 3. Detection of hIL11RA expression in Kidney in C57BL/6 and HO/HO hIL11/hIL11RA knock-in mice by IHC. Abbr. HO/HO, homozygous; WT, wild type. Note. The anti-human IL11RA Antibody cross-reacted with mouse IL11RA and humanized IL11RA.
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