| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-200275 |
|
Model Name |
IL2 & IL2RA |
|
Strain Name |
C57BL/6-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Asc |
|
GENE Synonyms |
Il-2; CD25, Il2r, IL-2R alpha chain, Ly-43 |
|
Human Orthologs |
IL2; IL2RA |
|
Ensembl ID |
ENSMUSG00000027720; ENSMUSG00000026770 |
|
MGI ID |
96548; 96549 |
|
NCBI ID |
16183; 16184 |
|
Background |
C57BL/6 |
|
Coat Color |
Black |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy, cancer research, drug screening |
|
Model Color |
Black |
IL2-HU (ASHU-190048) was crossed with IL2RA-HU (ASHU-190064) to generate humanized IL2 & IL2R mice.
Figure 1. Detection of hIL-2 expression by ELISA in the hIL-2 knock-in mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).
Figure 2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (Data in partnership with collaborators).
Figure 3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (Data in partnership with collaborators).
Figure 4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA humanized mouse (Data in partnership with collaborators).
Figure 5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (Data in partnership with collaborators).
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