| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-190018 |
|
Model Name |
LAG3 & CTLA4 |
|
Strain Name |
B6.129 – Lag3tm1(hLAG3)Ctla4em1(hCTLA4)/Asc |
|
GENE Synonyms |
Ly66, CD223, LAG-3; Cd152, Ly-56, Ctla-4 |
|
Human Orthologs |
LAG3; CTLA4 |
|
Ensembl ID |
ENSMUSG00000030124; ENSMUSG00000026011 |
|
MGI ID |
106588; 88556 |
|
NCBI ID |
16768; 12477 |
|
Background |
C57BL/6J |
|
Coat Color |
Black |
|
Mutation Type |
Humanized |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy |
|
Model Color |
Black |
This LAG3 and CTLA4 double Knock-in strain is established by crossing LAG3-HU and CTLA4-HU mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.
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