Lepr-(109052G>T)

SKU ASKI-00001 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-00001
Model Name	Lepr-(109052G>T)
Strain Name	B6.129-Leprtm1Asc
GENE Synonyms	db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like
Human Orthologs	LEPR
Ensembl ID	ENSMUSG00000057722
MGI ID	104993
NCBI ID	16847
Background	B6;129
Coat Color	Black
Model Type	Point mutaion
Research Application	Immunotherapy

A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.

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