Npc1-(I1060T)

SKU ASKI-18059 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-18059
Model Name	Npc1-(I1060T)
Strain Name	C57BL/6J-Npc1^{em1(I1060T)Asc}
GENE Synonyms	spm; lcsd; C85354; nmf164; D18Ertd139e; D18Ertd723e; A430089E03Rik
Human Orthologs	NPC1
Ensembl ID	ENSMUSG00000024413
MGI ID	1097712
NCBI ID	18145
Background	C57BL/6J
Coat Color	Black
Model Type	Point mutaion
Research Application	Immunotherapy

The I1060T point mutation is located in exon21 of mouse Npc1 gene. This Npc1 point mutation mouse model was established by introduce a T>C transversion at the 138th nucleotide of exon21 via CRISPR-mediated gene editing technology.

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