| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-190014 |
|
Model Name |
PD-1 & GITR |
|
Strain Name |
C57BL/6J – Pdcd1em1(hPDCD1) Tnfrsf18em1(hTNFRSF18)/Asc |
|
GENE Synonyms |
Ly101; AITR, Gitr |
|
Human Orthologs |
PDCD1; TNFRSF18 |
|
Ensembl ID |
ENSMUSG00000026285; ENSMUSG00000041954 |
|
MGI ID |
104879; 894675 |
|
NCBI ID |
18566; 21936 |
|
Background |
C57BL/6J |
|
Coat Color |
Black |
|
Mutation Type |
Humanized |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy |
|
Model Color |
Black |
The Programmed Cell Death Protein 1 (PDCD1) and the Glucocorticoid-induced TNFR-related protein (GITR) are inhibitory and co-stimulatory immune checkpoint proteins (respectively) that are key targets for current and developing cancer immunotherapies
This double humanized PD-1 and GITR mouse model was established by crossing the PD-1-HU and GITR-HU mice. This double knock-in mouse model is ideal for evaluating the efficacy of potential combination immunotherapy drugs.
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