PD-L1 (2)

Validation Data

Figure 1. The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis. 

Figure 2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.  

Figure 3. Immunotype in blood in hPD-L1 mice. 

Figure 4. Immunotype in spleen in hPD-L1 mice. 

Figure 5. Immunotype in bone marrow in hPD-L1 mice. 

Figure 6.  In vivo anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)

(A)  PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1.

(B) Mean body weight of mice.  All quantitative data are represented as mean ± SEM.