| Table Header | Table Header |
|---|---|
|
Catalog Number |
ASHU-00137 |
|
Model Name |
PD-L1 & LAG3 |
|
Strain Name |
C57BL/6J – Cd274em1(hPD – L1)Lag3tm1(hLAG3)/Asc |
|
GENE Synonyms |
B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, Ly66, CD223, LAG-3 |
|
Human Orthologs |
CD274, LAG3 |
|
Ensembl ID |
ENSMUSG00000016496, ENSMUSG00000030124 |
|
MGI ID |
1926446, 106588 |
|
NCBI ID |
60533, 16768 |
|
Background |
C57BL/6 |
|
Coat Color |
Black |
|
Mutation Type |
Humanized |
|
Model Type |
Humanized |
|
Research Application |
Immunotherapy, cancer research, drug screening |
|
Model Color |
Black |
Strategy for Generating Humanized PD-L1 (ASHU-00062) Mouse Model
Strategy for Generating Humanized LAG3 (ASHU-00049) Mouse Model
Figure 1. Splenocytes from homozygous hPDL1/hLAG3 mice were analyzed by flow cytometry after activation. The mPDL1+ and mLAG3+ cells were detectable in wild type (WT) C57BL/6 mice, while the hPDL1+ and hLAG3+ cells were detectable in the homozygous hPD1/hLAG3 mice.
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