R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato)

SKU ASKI-190010 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-190010
Model Name	R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato)
Strain Name	C57BL/6J-Gt(ROSA)26Sor^{em1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Asc}
Ensembl ID	ENSMUSG00000086429
MGI ID	104735
NCBI ID	14910
Background	C57BL/6J
Coat Color	Black
Model Type	Knock-in
Research Application	Immunotherapy

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus using CRISPR gene editing technology. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

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