R26-(Liver-CYP3A4)

SKU ASKI-18032 Category Other Gene Edited Mouse Models (KO, CKO)

Strain Information

Table Header	Table Header
Catalog Number	ASKI-18032
Model Name	R26-(Liver-CYP3A4)
Strain Name	FVB-Gt(ROSA)26Sor^{em1(Liver-CYP3A4)Asc}
GENE Synonyms	HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
Human Orthologs	CYP3A4
Ensembl ID	ENSG00000160868
NCBI ID	1576
Background	FVB
Coat Color	White
Model Type	Knock-in
Research Application	Immunotherapy

This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.

Ready to learn more?

Fill out the contact form below and a team member will be in touch within one business day.

Contact form