SIRPA (2) & CD47 & PD-1

SKU ASHU-2000090 Category Immune Checkpoint Mouse Models

Strain Information

Table Header	Table Header
Catalog Number	ASHU-2000090
Model Name	SIRPA (2) & CD47 & PD-1
Strain Name	C57BL/6 – Sirpa^tm2(hSIRPA)Cd47^em1(hCD47) Pdcd1^{em1(hPDCD1)/Asc}
GENE Synonyms	Bit, P84, SIRP, SHP-1, CD172a, Ptpns1, SHPS-1, AI835480, IAP, Itgp, Ly101
Human Orthologs	SIRPA, CD47, PDCD1
Ensembl ID	ENSMUSG00000037902, ENSMUSG00000055447, ENSMUSG00000026285
MGI ID	108563, 96617, 104879
NCBI ID	19261, 16423, 18566
Background	C57BL/6
Coat Color	Black
Mutation Type	Humanized
Model Type	Humanized
Research Application	Immunotherapy
Model Color	Black

This SIRPA，CD47 and PD-1 triple Knock-in strain is established by crossing hSIRPA, hCD47 and hPD-1 mice of three humanized strains together. These triple Knock-in mouse models can be useful for evaluating the efficacy of potential immunotherapy drug combinations

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