Save time by selecting and expressing proteins/antibodies directly in mammalian cells when you use TARGATT™ large knock-in technology
Whether you are interested in mammalian display, expressing multi-protein complexes, or looking for a gene expression technology that is compatible with high-throughput and automated pipelines, TARGATT™ technology is the proven choice.
With TARGATT™ CHO Kits, you can skip screening in bacteria and yeast and go straight to variant selection and optimization in the cell type you will manufacture in. You’ll save time and may even find variants you might have missed because of the differences in cellular physiology—especially cell membrane structure and glycosylation patterns.
Leveraging the power of site-specific integration and the consistently-expressing H11 safe harbor site, our TARGATT™ large knock-in technology enables genome engineering that CRISPR, transposons, and lentivirus can’t handle.
TARGATT™ Kits are designed to enable easy evaluation of the technology before purchasing a license*. Each TARGATT™ CHO Kit includes a CHO K1 cell line with the TARGATT™ landing pad already inserted into a safe harbor site, a donor plasmid for the DNA you are knocking in, a positive control plasmid for library kits, and a TARGATT™ Integrase expression plasmid.
We offer two safe harbor sites with our CHO kits to maximize your options—our general-purpose H11 safe harbor site (AST-1409, AST-1410, and AST-1420) and a second safe harbor site, A2, which provides an additional choice for gene expression.
*Academic researchers may purchase TARGATT™ technology without licensing. Request more information.
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If you are interested in outsourcing genome engineering, contact us for a custom service project quote.
Learn how TARGATT™ technology works and see the data—visit the technology page.
Because integration using TARGATT™ technology is so efficient, you can create highly diverse libraries and even perform mammalian display for screening in a biologically-relevant cell type.
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