$1,980.00
We use our efficient integration-free method to differentiate high-quality myoblasts from human iPSCs, with further differentiation into myotubes and skeletal muscle cells. The differentiated myoblasts recapitulate the phenotype and functional parameters of primary and in vivo myoblasts.
We provide cryopreserved myoblasts differentiated from an integration-free, control human iPSC line (ASE-9211), reprogrammed from fibroblasts of an African American male donor. These cryopreserved, high-purity (>90%) cells express high levels of myoblast biomarkers (CD56, Pax7, Myogenin) and form mature myotubes (skeletal muscle) characterized by elongated, multi-nucleated structures and the expression of myotube marker alpha-MHC in 4-6 days.
These iPSC-differentiated myoblasts/myotubes can be used as control lines to compare the phenotype and functionality of patient-derived and genome-edited iPSC-derived myoblasts/myotubes, for co-culture models with motor neurons (ASE-9701-1), and for toxicity and drug screening.
| Table Header | Table Header |
|---|---|
|
Age |
Neonate |
|
Gender |
Male |
|
Ethnicity |
African American |
|
Tissue source |
Dermal fibroblasts |
|
Reprogramming method |
Episomal |
|
Culture conditions |
Feeder-free |
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