Validation Data
Figure 1. The expression of human IL6 in liver tissue of humanized IL6/IL6R mice was measured by qPCR. The results showed that the active expression of humanized IL6 can be detected in liver tissue of homozygous humanized IL6/IL6R mice after LPS Activation.
Figure 2. Expression of human IL6 in the serum of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6 can be detected in the serum collected from homozygous mice after LPS Activation.
Figure 3. Expression of human IL6R in the serum, liver and pancreas of humanized IL6/IL6R homozygous mice is detected by Elisa. The results showed that the expression of human IL6R can be detected in the serum, liver and pancreas collected from homozygous mice.
Figure 4. Detection of hIL-6R expression in MM.1S cells.
Figure 5. Detection of hIL-6R expression in T cells in hIL-6/hIL-6R dKI mice.
Figure 6. Detection of hIL-6R expression in Myeloid cells, T cells and activated B cells in hIL-6/hIL-6R dKI mice. Note: Splenocytes from C57BL/6 and homozygous IL-6/hIL-6R mice were stimulated with LPS in vitro.
Figure 7. Detection of hIL-6R expression in brainstem in hIL-6/hIL-6R dKI mice by IHC.
Figure 8. Detection of hIL-6R expression in spleen in hIL-6 /hIL-6R dKI mice by IHC.
Figure 9. Detection of hIL-6R expression in lung and thymus in hIL-6 /hIL-6R dKI mice by IHC.
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