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PD-L1 & CTLA4

Name: PD-L1 &amp; CTLA4
SKU: ASHU-00102
Availability: InStock

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SKU: ASHU-00102

Categories: Animal Models, Immune Checkpoint Mouse Models, Mouse Repository, Research

Description
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Generation Strategy

Strategy for Generating Humanized PD-L1 (ASHU-00062) Mouse Model

landingpage-ashu-00102-PD-L1 & CTLA4-hu-icpmouse-1.1

Strategy for Generating Humanized CTLA4 (ASHU-00014) Mouse Model

Validation Data

Figure 1. Splenocytes from homozygous hPD-L1/hCTLA4 mice were analyzed by flow cytometry after activation. The murine Pd-l1 (mPD-L1) and Ctla4 (mCTLA4) positive cells were detectable in wild type (WT) C57BL/6 mice, while the human (hPD-L1) and human (hCTLA4) positive cells were detectable in the homozygous hCTLA4/hPD-L1 mice.

landingpage-ashu-00102-PD-L1 & CTLA4-hu-icpmouse-4

landingpage-ashu-00102- PD-L1 & CTLA4-hu-icpmouse-4

Figure 2. hCTLA-4/PD-L1 mice+ MC38 cells efficacy studies. We have developed a CTLA-4/PD-L1 dKI humanized model and tested the combined treatment of Yervoy and Tecentriq, and then observed improved efficacy in the combination treatment.

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Material Transfer Agreement

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This Material Transfer Agreement (“MTA”) is between you (“Purchaser”) and the Applied StemCell, Inc. a California company, having its principal place of business at 521 Cottonwood Drive Suite 111, Milpitas, CA 95035 USA (“ASC”). Purchaser must have an approved, current ASC account to place an order. This MTA is effective for a period of five (5) years as of the last date of execution by the parties and governs the purchase and use of all ASC Materials under the terms and conditions set forth below.

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PD-L1 & CTLA4

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Generation Strategy

Validation Data

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PD-L1 & CTLA4

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Generation Strategy

Validation Data

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MTA Agreement

Material Transfer Agreement

TERMS AND CONDITIONS

Definitions

Scope of Use

Warranty; Warranty Disclaimer

Limitation of Liability